Diabetes: there is no time to think, but to act, before suffering irreversible deterioration.



Diabetes affects millions of people, and it is not only the disease, but its subsequent complications that make it one of the most delicate pathologies to control and prevent.


In diabetes, insulin activity basically deteriorates, and over the years the ability of the pancreas to produce it and metabolize sugars worsens.


Due to lifestyle habits, sugar consumption, or an inadequate diet, a person who contracts diabetes disease is exposed to many other subsequent complications, such as damage to the circulation, high blood pressure, kidney failure, blindness, gangrene, poor healing ... and many others.



One of the main consequences of diabetes is suffered by the immune system, which due to the mismatch and proliferation of free radicals, almost loses all its ability to prevent the person from being exposed to infections –– which is the reason why they usually suffer gangrene, blindness and even being forced to amputate a limb.


In other words, the person with diabetes has damaged tissues and circulation, and his/her body with all this imbalance and overexertion wears down the levels of antioxidant defense; Here, the glutathione in the diabetic patient is overworking to neutralize more free radicals.


The most transparent study that we have found in relation to diabetes mellitus and oxidative stress is one that shows that oxidative stress and the decrease in antioxidant defense systems suffered by patients, most often than not, are followed by chronic complications.


This study also concludes that the antioxidant glutathione is able to contribute to reducing lipid peroxidation, the oxidation of LDL-cholesterol particles, and improving endothelial function and endothelium-dependent vasodilation.


The antioxidants you ingest daily and the glutathione supplement you choose to take play a very important role in defending your immune system and protecting your body from chronic diseases such as diabetes mellitus, cancer, and cardiovascular disease.


Thanks to these antioxidants and to glutathione ( the most powerful antioxidant) the increase of free radicals in the patient with diabetes mellitus are controlled, even if the disease is not cured, but it helps him/her not to suffer further complications if that oxidative stress is not controlled.


The study also suggests that glutathione could prevent and delay the development of chronic diabetes complications.


In the study we mention, it was found that the concentration of reduced glutathione is directly associated with the duration of the disease, in the case of insulin-dependent patients.



In other words, a person who does not have diabetes can suffer more or less, but controllable, oxidative damage if their glutathione levels are adequate.


However, when patients of diabetes are fighting oxidative stress, its no fight –– its a war. A war in which if they are not extremely careful to maintain their glutathione levels optimally, it is practically impossible to deal with the disease itself, plus its mentioned complications.


Conclusion:

1. Diabetes is one of the diseases in which free radicals form disproportionately, and almost impossible to control.


2. Simultaneously, and consequently, the levels of the antioxidant glutathione decrease dramatically.


3. This decrease in antioxidant defense exposes them more defenselessly to the subsequent complications associated with the disease, such as blindness, circulation problems, gangrene ...


4. The only ways to combat all of the above are:


  • Immediate and daily supplementation with liquid glutathione, and in amounts greater than those of a person in better conditions.


  • A healthy and sugar-free diet (not only from refined sugar, honey ... etc, but from the sugars contained in carbohydrates, fruits and other foods)


  • Daily physical activity.


With diabetes there is not much to think about, but rather to act. It is one of the most aggressive and quickest ways for free radicals, plus the aforementioned complications, to annul the quality of life of a person. Consequent complications can lead to irreversible deterioration.

___________________



References:


Evans JL, Goldfine IP, Maddus BA, Grodsky GM. Are oxidative stress-activated signalling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 2003.



Robertson R, Harmon J, Oanh P, Poitout V. Beta cell glucose toxicity, lipotoxicity and chronic oxidative stress in type 2 diabetes.


Giugliano D, Ceriello A, Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care.


Orasanu G, Plutzky J. The pathologic continuum of diabetes vascular disease. J Am Coll Cardiol 2009.


Yu Y, Lyons TJ. A lethal tread in diabetes, hyperglucemia, dyslipemia, oxidative stress and endothelial dysfunction. Am J Med Sci 2005


Forbes JM, Coughlan MT, Cooper ME. Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes2008.


Brown AA, Hu FB. Dietary modulation on endothelial function: implications for cardiovascular disease. Am J Clin Nutr 2001; 71: 673-86.


Ceriello A, Testa R. Antioxidant anti-inflammatory treatment in type 2 diabetes. Diabetes Care 2009; 32: S32-6.      


Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 2004.


Stamper MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 1993; 328: 1444-9.   

0 views

Contact Us. 

We'd love to hear from you!