Glutathione & Seizures

Glutathione plays an important role in the activity of the cells that develop in the brain, and for that reason it is also known as a neuromodulator.


A variety of studies have shown that when a person suffers from seizures the levels of glutathione in their organism decrease dramatically.


In electroencephalograms, it is important to notice how levels of Glutathione decrease in affected areas of the brain. Glutathione levels in patients with seizures are considerably lower than normal and this Glutathione deficiency is seen even more in those areas of the brain that have suffered seizures.


Extensive interpretations are found in a study conducted by the Department of Pediatric Neurology at the Children's Medical Center in Iran which indicate..

... that in fact, selenium and Glutathione peroxidase seem to play an important role in the pathogenesis of epilepsy, so its consumption is directly related to the activity of a brain that suffers from seizures.


Among other functions, Glutathione, “sweeps” electrical malfunctions of the brain, in order to give order and regulate brain activity. It’s important to note that after each seizure an intense electrical activity occurs which begins to generate free radicals. As a direct consequence, oxidative stress occurs, which is exactly what helps combat Glutathione. For this reason, it is vital to maintain high levels of the Glutathione compound.


When the conditions of the seizures are chronic or very common, they can damage the cells of the brain, causing neural damage - which is the destruction of cells.


Glutathione is a protector against seizures. Glutathione directly intervenes in the cell function of the brain because it participates in its activity (for that reason it is called a neuromodulator). In a study conducted at the Hospital of Toronto, scientists found that the combination of vitamin E with Glutathione minimizes damaged cells due to seizures. Similarly, in Italy there has been a variety of studies which prove that Glutathione prevents seizures.


It is safe to say that the neuromodulator property of glutathione validates its importance in the functioning of all the organs of the body.


References:

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1528-1167.2007.01143.x

Garcia-Ruiz C, Colell A, Morales A, Kaplowitz N, Fer- nandez-Checa JC. Role of oxidative stress generated from the mitochondrial electron transport chain and mi- tochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor kappa-β: studies with isolated mitochondria and rat hepatocytes. Mol Pharmacol 1995; 48 (5): 825-34.

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